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Otoacoustic emissions are clinically important because they are the basis of a simple, non-invasive test for hearing defects in newborn babies and in children who are too young to cooperate in conventional hearing tests. Many western countries now have national programmes for the universal hearing screening of newborn babies. Periodic early childhood hearing screenings program are also utilizing OAE technology. One excellent example has been demonstrated by the Early Childhood Hearing Outreach Initiative at the National Center for Hearing Assessment and Management (NCHAM) at Utah State University, which has helped hundreds of Early Head Start programs across the United States implement OAE screening and follow-up practices in those early childhood educational settings.[8][9][10] The primary screening tool is a test for the presence of a click-evoked OAE. Otoacoustic emissions also assist in differential diagnosis of cochlear and higher level hearing losses (e.g., auditory neuropathy).
The relationships between otoacoustic emissions and tinnitus have been explored. Several studies suggest that in about 6% to 12% of normal-hearing persons with tinnitus and SOAEs, the SOAEs are at least partly responsible for the tinnitus.[11] Studies have found that some subjects with tinnitus display oscillating or ringing EOAEs, and in these cases, it is hypothesized that the oscillating EOAEs and tinnitus are related to a common underlying pathology rather than the emissions being the source of the tinnitus.[11]
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The evoked responses from these stimuli occur at frequencies ( {\displaystyle f_{dp}} ) mathematically related to the primary frequencies, with the two most prominent being {\displaystyle f_{dp}=2f_{1}-f_{2}}  (the "cubic" distortion tone, most commonly used for hearing screening) and {\displaystyle f_{dp}=f_{2}-f_{1}}  (the "quadratic" distortion tone, or simple difference tone).[6][7]

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